The Big C: Season 2

Cathy seeks a second opinion, causing a strain on her relationship with Dr. Todd; Sean learns about his sister's cancer while adjusting to life with a pregnant Rebecca; Adam sees a therapist against his will.

Cathy finds that her experience with the great Dr. Atticus Sherman isn't anything like she thought it would be. Meanwhile, Cathy and Sean's relationship is still strained over the fact that she kept her illness a secret from him for so long.

Cathy and Paul experience frustration in the bedroom. Cathy and Paul need to set patient/caregiver limits, and Rebecca is put off by Sean.

A fellow cancer patient intrigues Cathy; Adam's downward spiral continues.

Paul still not having a job places a strain on his and Cathy's financial situation with mounting medical bills. Paul has to make a decision to wait for the perfect job, to do freelance work without insurance, or take any job that has insurance.

Although he still hates his job, Paul settles into life at the electronics store. He bonds with a fellow employee, a young Ukrainian immigrant named Mykail, who in turn bonds with one of his customers. While Paul still struggles with his job situation, Cathy aims for an extra job at the school with more pay as the girl's swim coach.

Cathy receives two minor pieces of bad news on her latest check up. The first is that none of the drugs' listed negative side effects have afflicted her, which to her means that the drugs aren't working. The second is that she has high blood pressure.

It's Thanksgiving, and Cathy and Paul are hosting their first ever Thanksgiving dinner with their new extended family, which includes not only Adam and Sean, but also Rebecca, Andrea, Mykail and if he accepts Lee, which he does. Cathy wants it to be a non-traditional meal.

Rebecca and Sean both have less than traditional ways to deal with Rebecca's miscarriage. Partly because Sean decides to go off his meds so that he can feel the true pain associated with it, Sean and Rebecca's methods of mourning end up being somewhat incompatible.

Following their Thanksgiving fallout, Cathy and Lee reconcile, with Cathy vowing to be honest with him about how things are progressing with her health. She sticks to that vow as her news is generally positive, while his continues to decline.

In her day life, Cathy runs into Dr. Sherman and his much younger second wife, Gia, who invites Cathy and Paul over for dinner. Not wanting to offend the person who is potentially saving her life, Cathy accepts. From dinner, Cathy learns a little bit about how to live in the face of death.

Cathy, Paul and Adam are getting ready to head to Italy for the Christmas holidays using Paul's cut from the electronics store thefts. They still haven't found Sean, but they feel they need to focus on themselves as a family. They are also leaving behind Andrea who is in engaged bliss to Mykail, with who she will spend the holidays.

Cathy believes the two best Christmas presents she received this year are Sean returning home after missing for three weeks while he went to find himself following Rebecca's departure, and watching Lee die peacefully in front of her, which has now made her not afraid of death.