Linda Danvers watches Prez Rickard on the television, as he speaks at a supermarket in Rosedale. She spots as assassin in the crowd and flies there as Supergirl. She arrives just in time to save the President. As Supergirl talks with Prez, a small boy asks him to fix his father's watch, which had stopped when his father died in Vietnam. Prez fiddles with the timepiece, fixing it in no time. Supergirl warns Prez to be careful and departs.
The President heads back to the White House but, on the way back, sees a sign for an auction of rare antique clocks. He can't resist, and instructs his driver to go to the auction site. Prez searches for a clock that doesn't work, so that he might fix it, and he finally locates one. Just as he is about to examine it, Supergirl, who had been keeping an eye on the President, swoops in and snatches it away. She flies off and the clock detonates safely outside. Supergirl returns and points out that there is a pattern in these attempts. She says that the plotters seem to know the President's route.
Television crews arrive and begin filming Prez and his guardian angel. Elsewhere, watching from his secret lab, is the mastermind of the assassination attempts. He observes as Supergirl flies off to the White House with the President. Prez comments that the plotters would never have expected the switch in plans. The mastermind tells his aide, a witch named Hepzibah, that Supergirl doesn't realize that the first two attempts were merely bait, and that the real assassin will be Supergirl herself. Hepzibah performs her evil magic on a Supergirl voodoo doll, commanding the heroine to kill the President. The mastermind boasts that he gets a million a contract by combining black magic with the wizardry of science. He then turns to his two lab assistants and instructs them to use radar to focus their large surgical laser probe on Supergirl. This radar-cranial cannon is designed to inflame the aggressive portion of the brain.
Supergirl suddenly feels the urge to kill the President. She lands on a high skyscraper and begins threatening him. Jets arrive and fire at Supergirl, but she just flies off with the President. High over a nearby river, Supergirl appears to drop him to his death! Shortly afterward, at the mastermind's hideout, the radar-cranial cannon is suddenly melted. Supergirl arrives, having tracked the radar beam back to the weapon. Soon, the police arrive and take the plotters away, but not before the mastermind gloats that at least she failed to stop him from killing the President.
Later, Prez appears on the television, revealing that Supergirl had flown him to the safety of the Fortress of Solitude, while using a plastic replica of him to deceive the gang. Supergirl comments that all she has from the experience is a slight headache.
Pretending to appeal to Supergirl for help in financing, geneticist Dr. Forte steals one cell from her hand with a "super-laser" and uses it to clone a male super-youth whom he calls Superlad. She is amazed to meet her "twin brother", but is appalled that he commits bank robberies to benefit Forte, and battles him. Superlad eludes her and goes to confront Forte, wondering why (as Supergirl has told him) he has not been given a sense of morality. Supergirl trails her clone to the lab of Dr. Forte. Forte orders Superlad to kill Supergirl with a super-laser gun. Instead, Superlad uses the gun on himself, committing suicide. Supergirl takes Dr. Forte captive.