Snowbird gives Dr. Mike a horse she wants to enter in the Territory Stakes horse race, but she must disguise herself as a man to qualify. Sully teaches her what to do to fool the race officials and helps her with strategies for the race.

Loren's sister-in-law Dorothy comes to town to flee her abusive husband. He ends up dead, and she is tried for his murder.

Mike is forced to rethink her relationship with Sully after a visit from his ex wife's ghost.

While hunting, Jake accidentally kills the Cheyenne brave Little Eagle and Sully tries to keep the peace between the Cheyenne and the town.

Dr. Mike and the reverend are skeptical when a so-called religious healer comes to town.

Dr. Quinn's mother in Boston is ill. Dr. Quinn takes the children to Boston.

Dr. Quinn has met a very nice doctor in Boston and is conflicted about staying.

There is a drought and no food for the town's Thanksgiving dinner. The townspeople fight over water.

Dorothy thinks she's pregnant, but Dr. Mike's exam reveals there are other problems going on. The upcoming Sweetheart Dance causes trouble between Sully and Dr. Mike. Colleen and Becky squabble over a boy, while Dr. Mike suspects something fishy going on between Sully and Dorothy.

Dr. Quinn is called away to a Flu epidemic in another town. Leaving Sully in charge of the children. But when there is an explosion at the railway, the military puts a bounty out for Sully. Sully is shot, leaving Colleen to treat him.

Dr. Mike has an "A Christmas Carol" style dream, where she wonders what her life would have been like if she had not become a doctor.

When the silver miners strike, Matthew is eager to take a scab job mining for the quick cash. But, with disastrous results.

The army brings supplies to the Cheyenne as an offering for their land. Dr. Quinn advises them to take the supplies in order to ease their suffering through the harsh winters. However, the supplies harbor a hidden surprise for the Cheyenne.

When a former circus performer and her daughter bring their circus to Colorado Springs, most of the town is recruited as performers.

A woman who has been living with Native Americans for over ten years is found and brought to Colorado Springs. Tensions rise between Sully and Mike when the girl becomes unusually attached to Sully.

When Rev. Johnson sponsors an orphan train in Colorado Springs, he finds placing the children in suitable homes may be harder then he anticipated.

A troop of buffalo soldiers comes to town and with them the idea that the government was using them instead of white soldiers, because it was felt they were more expendable.

Matthew gets hooked on gambling. Rev. Johnson's past catches up to him.

Dorothy's son returns from war with a problem that many vets came home with.

Robert E and Grace buy a house in town. A leader of the KKK comes to town and causes trouble among the citizens.

The town hires a new school teacher.

Doctor Mike is abducted by Native American Dog Soldiers. Brian tries to help an abused horse. General Custer and the Cavalry cause trouble.

With the help of Cloud Dancing and his son, Sully is determined to rescue Dr. Mike.

The town decides they need a town mayor. Jake Slicker and Dr. Mike are nominated to run against each other.

After Myra quits working for Hank, he gets drunk and shoots his gun during Myra's engagement party. Sully hits him with a tomahawk. Hank has a severe concussion and falls into a coma. Myra is the only one willing to stay by his side.

A stranger with close ties to Dr. Quinn comes to town with an agenda of his own.

Dr. Mike has a decision to make.