George Liquor (Michael Pataki) buys Ren and Stimpy (John Kricfalusi, Billy West) from a pet store and puts them on a rigorous training program; when Ren and Stimpy (John Kricfalusi, Billy West) are thrown into the pound, they start partying, until they realize what really happens if dogs aren't adopted in time.

Stimpy wins a competition that takes him to the Big-time in Hollywood. Ren, left at home, begins to miss Stimpy more than he ever would have thought. Will Stimpy, rich and successful, remember Ren and return home?

Ren Hoëk becomes "Robin Hoëk" in this parody of the Robin Hood legend. Stimpy, however, runs from scene to scene as he takes on the role of every other character. Next, stricken with an illness, Ren is brought back to health through Stimpy's unusual nursing practices. In some cases, the cure can be worse than the illness!

On their journey through space, Ren and Stimpy find that the true danger is "Space Madness", a cabin-crazy condition that Ren succumbs to. Next, in a sick tribute to classic animation, the two cook up a ploy to act as a rodent removal service. Ren becomes the mouse, and Stimpy as the cat. They take their services to suburbia with mixed results.

On the brink of starvation, and disguised as Dalmatians, the pair find employment at a fire station. Can these two handle an inferno at a towering skyscraper, with all of its exotic residents in need of rescue? Next, Stimpy, a little giant, and the brunt of the big giants' jokes, leaves home to find a happier life. What partnership will unfold when he meets Ren, a simple dairy farmer?

After a crash-landing on a strange planet, Commander Hoek and Cadet Stimpy go about cataloging and reporting on the strange planets inhabitants. But, before long, and quite unexpectedly, an inhabitant takes a very close look at them. Next, in kitsch documentary style, Ren narrates over some footage of curious flora and fauna. Finally, we are treated to a rare spotting of the Crocostimpy.

Commander Hoek and Cadet Stimpy are sucked into the hideous vortex of a black hole. Now as inhabitants on a new planet, and constantly mutating, the pair solve an age-old mystery after being tipped-off by a familiar smell. Next, Stimpy in his naive optimism, invents an emotion-controlling helmet. Ren, whether he likes it or not, is now the involuntary test-subject.