With Ethan, Sir Malcolm and Dr. Frankenstein now scattered around the world facing their own demons, a shattered and despondent Vanessa seeks the help of Dr. Seward to battle a new evil.

Sir Malcolm continues on his journey with the enigmatic Kaetenay. Meanwhile, Ethan gets some unexpected help from Hecate. Drs. Frankenstein and Jekyll hatch a plan, and unbeknownst to her, evil forces track Vanessa's every move.

Vanessa Ives is confronted by a familiar face who will reveal a clue to her past.

With the help of Dr. Seward, Vanessa undergoes hypnosis to relive her time in the Banning Clinic.

Hounded through the desert by Kaetenay and others, Ethan faces a reckoning. In London, Victor makes a dire modification to Jekyll's cure for madness.

Vanessa contacts her old friend Ferdinand Lyle for help. Lyle introduces her to Catriona Hartdegen. Lily, Dorian and Justine put their plan in motion. Ethan, Sir Malcolm and Hecate arrive at Talbot's ranch.

Lily sends her legion of women on a gruesome mission, Vanessa makes an ominous choice, and Kaetenay's visions drive Ethan toward his destiny.

While an apocalyptic pestilence enshrouds London, Victor decides Lily's fate and Ethan comes face-to-face with the evil that seduces Vanessa.

Sir Malcolm and his allies battle the fiend laying claim to Vanessa, the Creature faces a baleful demand, and Ethan makes a heartrending choice.