Grijpstra and De Gier investigate the murder on a middle-aged woman. During the investigation, De Gier comes across a girl he knows, and discovers that her boyfriend is a lover-boy. Hetty returns.

A controversial right-winged politician receives a bullet along with a threatening letter, but doesn't take it seriously and refuses police protection. When he is murdered shortly after, Grijpstra and De Gier suspect it to be a politically motivated murder. They also discover the man's younger brother is addicted to drugs and was about to be sent to a Scottish boarding school by him. Also, he once ran into a young girl, leaving her severely disabled, prompting suspicions that her father may have been out for revenge.

Grijpstra and De Gier investigate the murder of a beautiful young woman, and meet a man who is obsessed with dating women. The man reminds De Gier, who just got himself a new girlfriend again, of himself. The case escalates when Hetty disappears.

After a young boy is mistakenly shot in a botched assassination attempt, Grijpstra and De Gier try to find the culprit.

Grijpstra and De Gier investigate the murder on an unorthodox priest who sheltered homeless junkies. Possible suspects are the junkies themselves, and a pimp who was afraid the man might convince his prostitutes to stop working. The case is slowed by the fact that most of the police force has been sent to a fire on a retirement home; it later turns the niece of the chief's wife died in the disaster.

Businessman Rudolf Berkenrode has been hit by a car, leaving him brain-dead. Grijpstra and De Gier investigate, and discover that he owned a stretch of land including a shelter for victims of spousal abuse, whose owner blackmailed Berkenrode. He was also fighting with his stepdaughter. Cardozo discovers a connection between Berkenrode and Hetty.

Grijpstra and De Gier are in for a bizarre case when they find a praying Native American on the street with blood on his hands. Soon after, a dead man is found in the canal, and Grijpstra and De Gier save a man who was buried alive. Another death follows, and there may be a connection to the deaths and the four hemispheres of the Earth.

Grijpstra and De Gier investigate the murder on Marcel Corbijn, who was impaled with a harpoon. His father is a former colleague of the commissioner. Connections to an old trial are found, as well as a secret bank account on the Caiman Islands.